Abstract:
Detecion and Clinical Analysis of Urinary Iodine in Patients with Thyroid Tumor in TianjinLei LIU1, Yigong LI1, Xiangqian ZHENG1, Songfeng WEI1, Jiayu LIU2,Ming GAO1Corresponding author: Ming GAO, E-mail: gming68@yahoo.com.cn1Ddpartment of Head and Neck, Cancer Institute and Hospital of Tianjin Medical University,Tianjin 300060,China2Tianjin Institute of Endocrinology, Tianjin 300070, ChinaAbstract Objective: To study the relationship between thyroid tumor and urine iodine, and to discuss the evidence ofindividual iodine supplement. Methods: A total of 502 patients of Tianjin with 302 thyroid benign and 240 malignant tumorseen in our hospital between August 2009 and February 2010 were detected for urine iodine concentration and creatinineby arsenic-cerium catalytic spectrophotometry and method of alkaline picric acid. Meanwhile 400 normal people were setas the control group. Result: There was no significant difference between median urinary iodine ( MUI ) of benign thyroid tu-mor patients ( 519 μg/L ) and malignant thyroid tumor patients ( 524 μg/L )(P > 0.05) , which were both in excessive io-dine intake. MUI of the control group without thyroid disease was 201 μg/L, in adequate iodine intake, lower than that in theabove two groups ( P < 0.05 ). There was no significant difference in creatinine corrected daily urinary iodine ( CCDUI )among different age-sex groups in thyroid tumor patients(P > 0.05) . CCDUI of patients with lymph node metastasis andextrathyroidal invasion was respectively higher than that in patients without lymph node metastasis and extrathyroidal inva-sion ( P < 0.05 ). CCDUI of patients with benign thyroid papillary hyperplasia was higher than that in those without hyperpla-sia ( P < 0.05 ). CCDUI of patients with typical colloid thyroid goiter was higher than that in those without typical colloid thy-roid goiter ( P < 0.05 ). Conclusion: Iodine intake of patients with thyroid tumor in Tianjin may be excessive and should beadjusted by scientific and individual necessity.Keywords Urine iodine; Thyroid cancer ; Benign tumor